BCIT Citations Collection | BCIT Institutional Repository

BCIT Citations Collection

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Collection of published works from BCIT researchers, faculty, and instructors.

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How to qualify an analytical laboratory for analysis of herbal dietary ingredients and avoid using a "dry lab"
For better or for worse, many of the simple, unprocessed, and easily identifiable herbs of a bygone era can be found in retail commerce only rarely and with some degree of difficulty. Many modern botanical products intended for health-related purposes are, for the most part, quite complicated, often requiring additional testing for authentication of identity and for the presence of accidental or intentional adulterants, including contaminants such as heavy metals, pesticides, noxious microbes, and mycotoxins. As knowledge on the composition and properties of herbs has evolved, so too has the ability to evaluate those properties (e.g., marker compounds) using technology. The modern world also superimposes itself on commerce in the form of smelters, internal combustion engines, fecal coliforms, leaded gasoline, pesticides, prescription drugs, and other noxious substances that necessitate testing in addition to evaluating the inherent properties of the raw materials and finished products. No evaluation of herbal quality would be complete without some means of assuring that these and other unintentional contaminants are absent. In addition to an individual manufacturer’s desire to create and sell only the highest quality products, there are significant regulatory requirements surrounding the sale of botanical goods. Whether they are called natural health products (Canada), therapeutic goods (Australia), dietary supplements (United States), or phytomedicines (Europe), there are regulatory requirements to set specifications and to test for conformity with those specifications. Thus, the laboratory enters the scene., Article, Published.
Hygrothermal modeling of aerated concrete wall and comparison with field experiment
Proceedings of 3rd International Building Physics Conference: 27 August 2006, Montreal, QC. A two-dimensional heat, air and moisture transport model called hygIRC is adapted to simulate a well-documented field exposure of an aerated concrete wall section. Difficulties are encountered due to a few missing information on boundary conditions of the exposure and hygrothermal properties of aerated con-crete. The paper presents how these inadequacies were overcome to simulate the hygrothermal behavior of the wall section. Appropriate assumptions were made due to justifiable reasons. Then the model provides temporal and spatial distributions of temperature and relative humidity for an extended period that are in ex-cellent agreement with the documented field data. The paper presents the justifications for the assumptions and the comparison of experimental and simulation results., Conference paper, Published. A version of this document is published in: 3rd International Building Physics Conference, Montreal, QC., August 27, 2006, pp. 321-328.
Hygrothermal performance assessment of vented and ventilated wall systems
Proceedings of Thermal Performance of the Exterior Envelopes of Whole Buildings XII International Conference, At Clearwater Beach, Florida, USA, December 2013. Based on analysis of the drying and wetting potentials of a particular local climate, designers choose wall systems with or without an air gap between a sheathing membrane and a cladding layer. In addition to the capillary break that the air gap provides, thereby reducing the moisture transfer from wet cladding to the interior of the wall, the airspace will add the thermal resistance of the wall system and reduce the heat flow across the wall system. These moisture and thermal performances are straightforward to understand if the air in the air cavity is assumed to be a “still air.” In this paper, an experimental study is undertaken to under-stand the impact of airflow through an air cavity on the moisture and thermal performance of wall systems. To achieve this objective three test panels are instrumented and monitored in the field-experimental setting: one with no air gap, another one with an air gap but restricted airflow, and the third one with an air gap and open for airflow. The second and third wall systems have the same air gap width but different top flashing designs creating vented and ventilated wall systems. For the wall systems’ orientation and boundary conditions considered in this study, the wall with no air gap accumulates relatively high moisture content on the sheathing board, stud, and bottom plate and also has high moisture content changes in a year cycle when compared to the vented and ventilated wall systems. In general, the hygrothermal performances of vented and ventilated wall systems are comparable. During the winter period when relatively high moisture accumulation occurs, the upper section of the ventilated wall system shows slightly lower moisture content compared to that of the vented wall system. The temperature readings of the sheathing boards in the vented and ventilated wall systems are slightly warmer than that of the wall with no air gap for 85.5% and 73% of the time (based on hourly data of a year), respectively. For the balance of a period of time, the sheathing boards in the walls with an air cavity are slightly cooler than that of the wall with an air gap. Although the low temperature on the sheathing board, which is caused by solar radiation-induced airflow, is beneficial during a cooling season, the air gap and the associated airflow may reduce the heat gain that may be obtained from solar radiation during the heating season. The implications of air cavity and flashing design (airflow rate) on the heating and cooling load calculations of different orientations, wall configurations, and climate require further investigation., Conference paper, Published.
Hygrothermal performance of exterior wall systems using an innovative vapour retarder in Canadian climate
Proceeding of the 4th International Building Physics Conference: 15 June 2009, Istanbul, Turkey. This paper provides highlights of the research work carried out at the National Research Council Canada, Institute for Research in Construction on assessing the hygrothermal performance of wall systems that included this innovative vapour retarder (Note: Vapour Barrier in Canadian terminology is equivalent to Vapor retarder in US terminology). The performance of walls was assessed when subjected to eastern coastal climate conditions of Halifax, one of the four Canadian climatic locations used in this study. A wood-framed stucco clad wall was the reference assembly. Results from different cases based on the variation of vapour control strategies and their effect on the hygrothermal performance of the wall systems are analysed. The results for the Halifax climate location indicate that the installation of a humidity controlled, innovative vapour retarder is a recommendable solution for the envelope design of residential buildings of these locations with moderate or high water vapour permeance of the interior paint. In this study, the advanced hygrothermal tool, hygIRC, was used to perform the hygrothermal performance analysis of the wall systems., Peer reviewed article, Published. A version of this document is published in: 4th International Building Physics Conference, Istanbul, Turkey, June 15-18, 2009, pp. 1-8.
Hygrothermal performance of RH-dependent vapour retarder in Canadian coastal climate
Proceedings of 12th Canadian Conference of Building Science and Technology: 06 May 2009, Montreal, QC. The hygrothermal performance of wood-frame wall with stucco cladding exposed to the coastal climate of Vancouver, BC, is studied. The primary objective of the study is to compare the moisture management performance of two vapour barriers: the relatively new SmartVapour Retarder (SVR) and commonly used Polyethylene sheet. For a reference purpose a wood-frame wall with no vapour barrier is considered as well. The performances of these three walls, which are exposed to the same indoor and outdoor climatic loads, are compared with respect to their dynamic responses to two simulation variables: interior moisture load (simulated water intrusion in the stud cavity) and paint on the interior gypsum board. The water intrusion is assumed to be through defect areas and the quantity is correlated with the amount of wind-driven rain that the wall is exposed to. The hygrothermal simulation results suggest that adoption of SVR as a vapour barrier yields better moisture management of the sheathing board (OSB) for any conditions considered in this paper including internal moisture load and interior paint. But, in coastal climate, it may have adverse effect on the moisture management of the interior gypsum board, in cases where water leaks into the cavity and the interior gypsum board is painted with low-vapour permeance paint., Peer reviewed article, Published. A version of this document is published in: 12th Canadian Conference of Building Science and Technology, Montreal, QC, May 6-8, 2009, pp. 1-12
Hygrothermal performance of ventilated attic in marine climate under different ceiling air tightness
14th International Conference on Indoor Air Quality and Climate (Indoor Air 2016), July 3-8, 2016, Ghent, Belgium. An indoor to attic air leakage and vice-versa significantly affect indoor air, thermal comfort and the hygrothermal performance in both living space and unconditioned space. In cold and marine climates an air leakage from living space to an attic brings a relatively high relative humidity to the attic space. This effect is primarily responsible for condensation in attic structural parts such as roof sheathings. In this paper, the hygrothermal performance of a ventilated attic in wet costal climates under different ceiling air leakage is studied. A benchmarked whole building Heat-Air-Moisture model named HAMFit is used to study hygrothermal performance of ventilated attics in marine climates. The attic is modelled as 2-dimensional geometry with coupled heat transfer, moisture transport and a turbulence Computational Fluid Dynamics through attic space and porous structural parts of the attic. A vent ratio of 1/300 and three types normalized leakage area (tight, normal and leaky) are used to analyse how the moisture transport behaves in ventilated space. A winter weather data of city of Vancouver, BC is used to represent a wet marine climate. Our findings show specific locations in the attic structure are more exposed to moisture related problems and the air circulation and temperature distribution due to ventilation under multiple ceiling air leakage scenarios are presented. Hygrothermal performance of ventilated attic in marine climate under different ceiling air tightness., Conference paper, Published.
Hygrothermal properties of exterior claddings, sheathing boards, membranes and insulation materials for building envelope design
Proceedings of Thermal Performance of the Exterior Envelopes of Whole Buildings X International Conference: 02 December 2007, Clearwater, Florida. Testing was conducted to determine those construction material properties that affect the movement of heat, air, and moisture in building envelopes. The paper reports the density, thermal conductivity, equilibrium moisture content, water vapor permeability, water absorption coefficient, liquid diffusivity, and air permeability of twenty-three building materials commonly used in North American including: exterior claddings, exterior sheathing boards, membranes and insulations. The paper also discusses the experimental and analytical procedures used to determine these properties., Conference paper, Published. A version of this document is published in: Proceedings of Thermal Performance of the Exterior Envelopes of Whole Buildings X, Clearwater, Florida, Dec. 2-7, 2007, pp. 1-16.
Identification of quantitative trait loci controlling fibre length and lignin content in Arabidopsis thaliana stems
Fibre properties and the biochemical composition of cell walls are important traits in many applications. For example, the lengths of fibres define the strength and quality of paper, and lignin content is a critical parameter for the use of biomass in biofuel production. Identifying genes controlling these traits is comparatively difficult in woody species, because of long generation times and limited amenability to high-resolution genetic mapping. To address this problem, this study mapped quantitative trait loci (QTLs) defining fibre length and lignin content in the Arabidopsis recombinant inbred line population Col-4×Ler-0. Adapting high-throughput phenotyping techniques for both traits for measurements in Arabidopsis inflorescence stems identified significant QTLs for fibre length on chromosomes 2 and 5, as well as one significant QTL affecting lignin content on chromosome 2. For fibre length, total variation within the population was 208% higher than between parental lines and the identified QTLs explained 50.58% of the observed variation. For lignin content, the values were 261 and 26.51%, respectively. Bioinformatics analysis of the associated intervals identified a number of candidate genes for fibre length and lignin content. This study demonstrates that molecular mapping of QTLs pertaining to wood and fibre properties is possible in Arabidopsis, which substantially broadens the use of Arabidopsis as a model species for the functional characterization of plant genes., Peer-reviewed article, Published. Received 3 April 2012; Revised 11 October 2012; Accepted 15 October 2012.
Impact of electrical intertie capacity on carbon policy effectiveness
This study investigates the potential cost and emissions reductions that result from an increase in electricity transmission capacity between Canada's two westernmost provinces: Alberta, a fossil fuel dominated jurisdiction, and British Columbia, a predominantly hydroelectric jurisdiction. A bottom-up model is used to find the least cost electricity generation mix in Alberta and British Columbia under different carbon policies. The long-term evolution of the electricity system is determined by minimizing net present cost of electricity generation for the time span of 2010–2060. Different levels of intertie capacity expansion are considered together with a variety of carbon tax and carbon cap scenarios. Results indicate that increased intertie capacity reduces the cost of electricity and emissions under carbon pricing policies. However, the expandable intertie does not encourage greater adoption of variable renewable generation. Instead, it is used to move low-cost energy from the United States to Alberta. The optimal intertie capacity and cost reduction of increased interconnectivity increases with more restrictive carbon policies., Peer-reviewed article, Published. Received 3 March 2016, Revised 23 September 2016, Accepted 12 October 2016, Available online 15 November 2016.
The impact of spinal cord injury on sexual function
Study Design: Secure, web-based survey. Objectives: Obtain information from the spinal cord injured (SCI) population regarding sexual dysfunctions, with the aim of developing new basic science and clinical research and eventual therapies targeting these issues. Setting: Worldwide web. Methods: Individuals 18 years or older living with SCI. Participants obtained a pass-code to enter a secure website and answered survey questions. A total of 286 subjects completed the survey. Results: The majority of participants stated that their SCI altered their sexual sense of self and that improving their sexual function would improve their quality of life (QoL). The primary reason for pursuing sexual activity was for intimacy need, not fertility. Bladder and bowel concerns during sexual activity were not strong enough to deter the majority of the population from engaging in sexual activity. However, in the subset of individuals concerned about bladder and/or bowel incontinence during sexual activity, this was a highly significant issue. In addition, the occurrence of autonomic dysreflexia (AD) during typical bladder or bowel care was a significant variable predicting the occurrence and distress of AD during sexual activity. Conclusion: Sexual function and its resultant impact on QoL is a major issue to an overwhelming majority of people living with SCI. This certainly constitutes the need for expanding research in multiple aspects to develop future therapeutic interventions for sexual health and SCI., Peer-reviewed article, Published.
The impact of step targeting during normal gait for persons wearing either a SACH or a dynamic-response foot
This study compared dynamic-response feet to SACH feet with respect to factors influencing unilateral transtibial amputee balance and ability to adapt to variable terrains. This was done by measuring ground reaction forces for 30% perturbations of step length during level walking. These perturbations resulted in either a lengthening or a shortening of one step length by 30% of the normal step length. Subjects walked along a 12 metre walkway and across two flush mounter force platforms while forces were recorded for both feet. Three experimental conditions were completed with each foot type: normal step length, short step length (reduced by 30% from normal), and long step length (increased by 30% from normal)., Research report, Published.
The importance of method selection in determining product integrity for nutrition research
The American Herbal Products Association estimates that there as many as 3000 plant species in commerce. The FDA estimates that there are about 85,000 dietary supplement products in the marketplace. The pace of product innovation far exceeds that of analytical methods development and validation, with new ingredients, matrixes, and combinations resulting in an analytical community that has been unable to keep up. This has led to a lack of validated analytical methods for dietary supplements and to inappropriate method selection where methods do exist. Only after rigorous validation procedures to ensure that methods are fit for purpose should they be used in a routine setting to verify product authenticity and quality. By following systematic procedures and establishing performance requirements for analytical methods before method development and validation, methods can be developed that are both valid and fit for purpose. This review summarizes advances in method selection, development, and validation regarding herbal supplement analysis and provides several documented examples of inappropriate method selection and application., Peer-reviewed article, Published.
Improved dynamic friction models for simulation of one-dimensional and two-dimensional stick-slip motion
In many mechanical systems, the tendency of sliding components to intermittently stick and slip leads to undesirable performance, vibration, and control behaviors. Computer simulations of mechanical systems with friction are difficult because of the strongly nonlinear behavior of the friction force near zero sliding velocity. In this paper, two improved friction models are proposed. One model is based on the force-balance method and the other model uses a spring-damper during sticking. The models are tested on hundreds of lumped mass-spring-damper systems with time-varying excitation and normal contact forces for both one-dimensional and two-dimensional stick-slip motions on a planar surface. Piece-wise continuous analytical solutions are compared with solutions using other published force-balance and spring-damper friction models. A method has been developed to set the size of the velocity window for Karnopp’s friction model. The extensive test results show that the new force-balance algorithm gives much lower sticking velocity errors compared to the original method and that the new spring-damper algorithm exhibits no spikes at the beginning of sticking. Weibull distributions of the sticking velocity errors enable maximum errors to be estimated a priori., Technical papers, Published. Received February 03, 2000; Revised August 17, 2000.
Improving students' engagement with large-team software development projects
Proceedings from the 23rd Annual ACM Conference on Innovation and Technology in Computer Science Education. Computer science and technology education should provide not only a strong theoretical foundation, but also problem solving, and communication and teamwork skills to prepare the students for careers. Including projects in curricula is a norm in many disciplines. However, projects are generally individual or based on small teams (two to five members). This paper presents my approach to teaching a capstone undergraduate computer technology course at the British Columbia Institute of Technology (BCIT) in the Computer System Technology (CST) Program in which a large class of students (maximum 22), organized into small teams work together and apply Agile software development practices to design, implement, integrate and test a large project. This model provides students with unique learning opportunities and experiences, as well as improving their soft skills, engagement and motivation., Peer reviewed, Conference paper, Published.
In silico evolution of gene cooption in pattern-forming gene networks
Gene recruitment or cooption occurs when a gene, which may be part of an existing gene regulatory network (GRN), comes under the control of a new regulatory system. Such re-arrangement of pre-existing networks is likely more common for increasing genomic complexity than the creation of new genes. Using evolutionary computations (EC), we investigate how cooption affects the evolvability, outgrowth and robustness of GRNs. We use a data-driven model of insect segmentation, for the fruit fly Drosophila, and evaluate fitness by robustness to maternal variability—a major constraint in biological development. We compare two mechanisms of gene cooption: a simpler one with gene Introduction and Withdrawal operators; and one in which GRN elements can be altered by transposon infection. Starting from a minimal 2-gene network, insufficient for fitting the Drosophila gene expression patterns, we find a general trend of coopting available genes into the GRN, in order to better fit the data. With the transposon mechanism, we find co-evolutionary oscillations between genes and their transposons. These oscillations may offer a new technique in EC for overcoming premature convergence. Finally, we comment on how a differential equations (in contrast to Boolean) approach is necessary for addressing realistic continuous variation in biochemical parameters., Peer-reviewed article, Published. Received 29 September 2012; Accepted 13 November 2012.
In silico evolution of the hunchback gene indicates redundancy in cis-regulatory organization and spatial gene expression
Biological development depends on the coordinated expression of genes in time and space. Developmental genes have extensive cis-regulatory regions which control their expression. These regions are organized in a modular manner, with different modules controlling expression at different times and locations. Both how modularity evolved and what function it serves are open questions. We present a computational model for the cis-regulation of the hunchback (hb) gene in the fruit fly (Drosophila). We simulate evolution (using an evolutionary computation approach from computer science) to find the optimal cis-regulatory arrangements for fitting experimental hb expression patterns. We find that the cis-regulatory region tends to readily evolve modularity. These cis-regulatory modules (CRMs) do not tend to control single spatial domains, but show a multi-CRM/multi-domain correspondence. We find that the CRM-domain correspondence seen in Drosophila evolves with a high probability in our model, supporting the biological relevance of the approach. The partial redundancy resulting from multi-CRM control may confer some biological robustness against corruption of regulatory sequences. The technique developed on hb could readily be applied to other multi-CRM developmental genes., Peer-reviewed article, Published.

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