Proceedings of the World Congress on Engineering and Computer Science 2007 WCECS 2007, October 24-26, 2007, San Francisco, USA. Gene recruitment or co-option is defined as the placement of a gene under a foreign regulatory system. Such re-arrangement of pre-existing regulatory networks can lead to an increase in genomic complexity. This reorganization is recognized as a major driving force in evolution. We simulated the evolution of gene networks by means of the Genetic Algorithms (GA) technique. We used standard GA methods of (point) mutation and multi-point crossover, as well as our own operators for introducing or withdrawing new genes on the network. The starting point for our computer evolutionary experiments was a minimal 4-gene dynamic model representing the real genetic network controlling segmentation in the fruit fly Drosophila. Model output was fit to experimentally observed gene expression patterns in the early fly embryo. We found that the mutation operator, together with the gene introduction procedure, was sufficient for recruiting new genes into pre-existing networks. Reinforcement of the evolutionary search by crossover operators facilitates this recruitment. Gene recruitment causes outgrowth of an evolving network, resulting in structural and functional redundancy. Such redundancies can affect the robustness and evolvability of networks., Conference paper, Published.
There appears to be an increased risk of cardiovascular disease (CVD) among individuals with spinal cord injury. Quantitative data concerning the risk of heart disease among individuals with other neurological disorders (NDs) are not available. Our aim was to estimate the prevalence of heart disease among individuals with NDs and to compare their risk with a control group., Article, Published. Received: September 19, 2014 ; Accepted: January 05, 2015 ; Published online: February 17, 2015 ; Issue release date: March 2015.
The Prosthetics and Orthotics Department at the British Columbia Institute of Technology (BCIT) in Vancouver, Canada, has recently completed a visioning process which was done as part of a curriculum review. This report presents and discusses the key points emerging from the process. It is anticipated that the results of the visioning process will provide a basis for a major curriculum revision to the BCIT’s prosthetics and orthotics program. The intent of a curriculum review is to determine whether an educational program’s curriculum is current and relevant with respect to providing students with entry-level skills for the workforce. It involves examining the current scope of practice and competencies of the profession in question and then reflecting back on the curriculum to determine whether these competencies are being taught adequately. Visioning attempts to determine not what entry-level skills graduates require but, instead, what knowledge and skills students need to meet the challenges of the workplace approximately 10 to 15 years into the future., Peer-reviewed article, Published.
Prepared for the Atlantic Canada Economic Association Conference, October 19-20, 2012, Halifax Nova Scotia. Both the Canada and United States invest a great deal of resources in the training of their military personal. Many of the skills and experiences accumulated by soldiers are those that are highly valued by civilian employers. Further, these skills are often embodied in academic programs, suggesting soldiers would have a comparative advantage in such programs; however, despite the efforts of government agencies, many soldiers are unable to convert their skills and training into meaningful careers. This paper presents the findings from a pilot program at the BC institute of Technology 2009-2012. The program uses an alternative approach to assessing military training for advanced placement into post-secondary programs. By mapping learning outcomes rather than course equivalences, those from non-traditional education backgrounds are given advanced placement into post-secondary programs. During the pilot period, a cohort of reservists and veterans who have been given advanced placement are tracked and benchmarked against regular students in the same programs over time, measuring academic scores and testing for the development of skills, abilities, and qualities considered important for workplace success., Conference paper, Draft available.
Proceedings of the 2011 International Conference on Evolutionary Computation Theory and Applications. Classical understandings of biological evolution inspired creation of the entire order of Evolutionary Computation (EC) heuristic optimization techniques. In turn, the development of EC has shown how living organisms use biomolecular implementations of these techniques to solve particular problems in survival and adaptation. An example of such a natural Genetic Algorithm (GA) is the way in which a higher organism's adaptive immune system selects antibodies and competes against its complement, the development of antigen variability by pathogenic organisms. In our approach, we use operators that implement the reproduction and diversification of genetic material in a manner inspired by retroviral reproduction and a genetic-engineering technique known as DNA shuffling. We call this approach Retroviral Genetic Algorithms, or retroGA (Spirov and Holloway, 2010). Here, we extend retroGA to include: (1) the utilization of tags in strings; (2) the capability of the Reproduction-Crossover operator to read these tags and interpret them as instructions; and (3), as a consequence, to use more than one reproductive strategy. We validated the efficacy of the extended retroGA technique with benchmark tests on concatenated trap functions and compared these with Royal Road and Royal Staircase functions., Conference paper, Published.
Since the 1800s, natural health products that contain hawthorn (Crataegus spp.) have been used in North America for the treatment of heart problems such as hypertension, angina, arrhythmia, and congestive heart failure. Traditionally, Native American tribes used hawthorn (Crataegus spp.) to treat gastrointestinal ailments and heart problems, and consumed the fruit as food. Hawthorn also has a long history of use in Europe and China for food, and in traditional medicine. Investigations of Crataegus spp. typically focus on the identification and quantification of flavonoids and anthocyanins, which have been shown to have pharmacological activity. The main flavonoids found in Crataegus spp. are hyperoside, vitexin, and additional glycosylated derivatives of these compounds. Reviewed herein are the botany, ethnobotany, and traditional use of hawthorn while focusing on the phytochemicals that have been reported in Crataegus species, and the variation in the described chemistry between individual species., Peer-reviewed article, Published. Received 4 July 2011; Revised 9 December 2011; Available online 17 May 2012.
Dorsal rhizotomy results in primary deafferentation of the dorsal horn with concomitant sprouting of spared intraspinal monoaminergic axons. Because descending monoaminergic systems are thought to mitigate nociceptive transmission from the periphery and because dorsal rhizotomy can result in neuropathic pain, we sought to determine whether the rhizotomy-induced sprouting response could be further augmented. Because myelin-derived molecules mask endogenous plasticity of CNS axons and because myelin-inhibitory signaling occurs through the Rho-GTPase pathway, we inhibited Rho-pathway signaling after cervical dorsal rhizotomy in rats. An increase in the density of serotonergic- and tyrosine hydroxylase-positive fibers was seen in the dorsal horn 1 week after septuple rhizotomy, and axon density continued to increase for at least 1 month. One week after septuple rhizotomy, administration of intrathecal Y-27632, an antagonist of Rho-kinase (ROCK), increased the density of both fiber types over vehicle-treated controls. To examine behavioral effects of both cervical rhizotomy and ROCK inhibition, we examined responses to evoked pain: mechanical and thermal allodynia and cold hyperalgesia in the forepaw were examined after single, double, and quadruple rhizotomies of dorsal roots of the brachial plexus. The most notable behavioral outcome was the development of cold hyperalgesia in the affected forepaw after rhizotomies of the C7 and C8 dorsal roots. Application of Y-27632 both attenuated cold hyperalgesia and induced monoaminergic plasticity after C7/8 rhizotomy. Thus, inhibition of Rho-pathway signaling both promoted the sprouting of intact supraspinal monoaminergic fibers and alleviated pain after dorsal rhizotomy., Peer-reviewed article, Published. Received July 6, 2004; revised Oct. 3, 2004; accepted Oct. 18, 2004.
"Gives voice to more than fifty extraordinary people who are currently engaged with this transformation. These individuals form a diverse community that cuts across professional disciplines, cultural, linguistic and gergraphical boundaries. They share a belief that they can make a difference through their varied efforts to expand living architectural approaches that result in biophilic, restorative buildings and healthier and more resilient communities." Profiles more than 50 of the hundreds of leaders that have created the base and molded the foundation of living architecture., Book, Published.
Smart grid-related blogs, newsletters, and conferences have endured numerous debates and discussions around the issue of whether or not the smart grid integrated correctly. While most debates focus on approach, methodology, and the sequence of what to be done, there is insufficient discussion about actually meant by "smart grid integration." This article attempts to present a holistic view of integration and argues for the importance of developing system integration “maps” based on a utility's strategic smart grid road map., Article, Published
The transplantation of Schwann cells (SCs) holds considerable promise as a therapy for spinal cord injury, but the optimal source of these cells and the best timing for intervention remains debatable. Previously, we demonstrated that delayed transplantation of SCs generated from neonatal mouse skin-derived precursors (SKP-SCs) promoted repair and functional recovery in rats with thoracic contusions. Here, we conducted two experiments using neonatal rat cells and an incomplete cervical injury model to examine the efficacy of acute SKP-SC transplantation versus media control (Experiment 1) and versus nerve-derived SC or dermal fibroblast (Fibro) transplantation (Experiment 2). Despite limited graft survival, by 10 weeks after injury, rats that received SCs from either source showed improved functional recovery compared with media- or fibroblast-treated animals. Compared with media treatment, SKP-SC-transplanted rats showed enhanced rubrospinal tract (RST) sparing/plasticity in the gray matter (GM) rostral to injury, particularly in the absence of immunosuppression. The functional benefits of SC transplantations over fibroblast treatment correlated with the enhanced preservation of host tissue, reduced RST atrophy, and/or increased RST sparing/plasticity in the GM. In summary, our results indicate that: (1) early transplantation of neonatal SCs generated from skin or nerve promotes repair and functional recovery after incomplete cervical crush injury; (2) either of these cell types is preferable to Fibros for these purposes; and (3) age-matched SCs from these two sources do not differ in terms of their reparative effects or functional efficacy after transplantation into the injured cervical spinal cord., Peer-reviewed article, Published.Received March 17, 2014; revised March 18, 2015; accepted March 21, 2015.
Proceedings of 2015 RESNA Annual Conference. In recent years, more and more studies are using data logger technologies to document driving and physiological characteristics of manual wheelchair users. However, the technologies used offer marked differences in characteristics such as measured outcomes, ease of use, burden, etc. The objective of this study is to examine the extent of research activity that relied on data logger technologies for manual wheelchair users. We undertook a scoping review of the scientific and gray literature. Five databases were searched from January 1979 to November 2014: Medline, Compendex, CINAHL, EMBASE and Google Scholar. This review retained 104 papers. The selected papers document a wide variety of systems and technologies, measuring a whole range of outcomes. Of all technologies combined, 16.8% were accelerometers installed on the user, 14.8% were magnetic odometers or odometers installed on the wheelchair, 10.2% were accelerometers installed on the wheelchair and 8.67% were heart monitors. So, it is not surprising that the most reported outcomes were distance, speed and acceleration of the wheelchair, and heart rate. In the future, it may be necessary to reach a consensus on what outcomes are important to measure and how. Technological improvements and access to less expensive devices will probably make it possible to easily measure many important outcomes at relatively low cost., Conference paper, Published.
Proceedings from the 2017 ACM Conference on Innovation and Technology in Computer Science Education. Drawing on the long debate about whether computer science (CS) and computational thinking skills are innate or learnable, this working group is based on the following hypothesis: The apparent innate ability of some CS learners who succeed in CS courses despite no prior exposure to computing is a manifestation of early childhood experiences and learning outside formal education., Peer reviewed, Conference paper, Published., K-12 education, Computational thinking