Stochastic dynamics of gene expression in developing fly embryos
Holloway, D., & Spirov, A. , V. (2017). Stochastic dynamics of gene expression in developing fly embryos. 2017 International Conference On Noise And Fluctuations (Icnf), 1-4. doi:https://doi.org/10.1109/ICNF.2017.7985933
Proceedings of 2017 International Conference on Noise and Fluctuations (ICNF), Vilnius, Lithuania on 20-23 June 2017. Segmentation of the developing insect body is preceded by cell-specific gene expression. In fruit flies (Drosophila), pair-rule genes are expressed in spatial stripes specifying segment fates. Transcription of the even-skipped (eve) pair-rule gene was recently shown to proceed in noisy bursts. Here, we develop a stochastic model of eve transcription from DNA to mRNA. This indicates that eve transcription proceeds at two rates, with a slow rate providing basal production and a fast rate allowing for high mRNA output. This two-rate transcription may afford more reliability in mRNA output, and therefore the protein levels which specify cell type, than a simple on-off (one-rate) mechanism., Conference paper, Published.
